Обзорная статья

A framework for advancing our understanding of cancer-associated fibroblasts

Erik SahaiThe Francis Crick Institute, London, UK. [email protected]Igor AstsaturovMarvin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA, USAEdna CukiermanCancer Biology Program, Marvin & Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA, USADavid G. DeNardoDivision of Oncology, Washington University Medical School, St Louis, MO, USAMikala EgebladCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USARonald M. EvansGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USADouglas T. FearonCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USAFlorian R. GretenFrankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt, GermanySunil R. HingoraniFred Hutchinson Cancer Research Center, Seattle, WA, USATony HunterMolecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USARichard O. HynesKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USARakesh K. JainEdwin L Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USATobias JanowitzCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USAClaus JørgensenCancer Research UK Manchester Institute, University of Manchester, Nether Alderley, UKAlec C. KimmelmanDepartment of Radiation Oncology, Perlmutter Cancer Center, New York University Medical Center, New York, NY, USAMikhail G. KoloninBrown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Houston, TX, USARobert G. MakiAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USAScott PowersDepartment of Pathology, Stony Brook University, Stony Brook, NY, USAEllen PuréDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USADaniel C. RamirezZucker School of Medicine at Hofstra/Northwell Health System, New York, NY, USARuth Scherz‐ShouvalDepartment of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, IsraelMara H. ShermanDepartment of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR, USASheila A. StewartDepartment of Cell Biology and Physiology, Department of Medicine, ICCE Institute, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USAThea D. TlstyDepartment of Pathology, UCSF, San Francisco, CA, USADavid A. TuvesonCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USAFiona M. WattCentre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, London, UKValerie M. WeaverCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA, USAAshani T. WeeraratnaSidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USAZena WerbDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, USA

2020en

ABI

Аннотация

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment.

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Идентификаторы

DOI: 10.1038/s41568-019-0238-1

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar