The lignicolous fungus <i>Trametes versicolor</i> (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents
Ljiljana JanjuševićMaja KaramanFilip ŠibulDepartment of Chemistry and Biochemistry, University of Novi Sad, Novi Sad, Serbia;Giuseppina TommonaroCNR-ICB, National Research Council of Italy, Institute of Biomolecular Chemistry, Pozzuoli (Naples), Italy;Carmine IodiceCNR-ICB, National Research Council of Italy, Institute of Biomolecular Chemistry, Pozzuoli (Naples), Italy;Dragica JakovljevićCentre of Chemistry, Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade, Serbia;Boris PejinDepartment of Life Sciences, Institute for Multidisciplinary Research – IMSI, University of Belgrade, Belgrade, Serbia
2017en
ABI
Аннотация
OH (3.21 μg/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 μg/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer's disease.
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