Обзорная статья

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

Khalid KarrouchiLCAE, Department of Chemistry, Faculty of Sciences, University Mohamed I, 60000 Oujda, MoroccoSmaail RadiLCAE, Department of Chemistry, Faculty of Sciences, University Mohamed I, 60000 Oujda, MoroccoYoussef RamliMedicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10100 Rabat, MoroccoJamal TaoufikMedicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10100 Rabat, MoroccoYahia N. MabkhotDepartment of Chemistry, Faculty of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaFaiz A. Al‐aizariDepartment of Chemistry, Faculty of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaM’hammed AnsarMedicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10100 Rabat, Morocco

2018en

ABI

Аннотация

Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antipsychotic CDPPB, the anti-obesity drug rimonabant, difenamizole, an analgesic, betazole, a H2-receptor agonist and the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Owing to this diversity in the biological field, this nucleus has attracted the attention of many researchers to study its skeleton chemically and biologically. This review highlights the different synthesis methods and the pharmacological properties of pyrazole derivatives. Studies on the synthesis and biological activity of pyrazole derivatives developed by many scientists around the globe are reported.

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Идентификаторы

DOI: 10.3390/molecules23010134

Цитирования и источники

Цитирований: 4Использованных источников: 0

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