Synthesis and antibacterial activity of some 5,5'-(1,4-phenylene)-bis-1,3,4-oxadiazole and bis-1,2,4-triazole derivatives as precursors of new S-nucleosides

Five compounds, namely 5,5’-benzene-1,4-diylbis(1,3,4-oxadiazole-2-thiol)6 and 5,5’-benzene-1,4-diylbis(1 H -1,2,4-triazole-3-thiol) 7a  and its derivatives 7b–d were synthesized. Two related S -nucleosides 9 and 10 have been prepared from 6 and 7a . Some of these synthesized compounds were tested in vitro by spotting on Mueller Hinton Agar medium against some Gram-positive bacteria,  Staphylococcus aureus and Enterococcus faecalis and three Gram-negative bacteria Escherichia coli , Pseudomonas aeruginosa ,  Pseudomonas fluorescens and compared with the known antibiotics cephalosporin (cefotaxim) and gentamycin. Compound 6 showed significant inhibitory activity against Gram-positive E. faecalis and Gram-negative E. coli bacteria while the others have shown variable inhibition activity. Keywords:  Terephthalic acid, 1,3,4-oxadiazole, 1 H -1,2,4-triazole, S -nucleosides, antimicrobial activity

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