Обзорная статья

Disorders of cancer metabolism: The therapeutic potential of cannabinoids

Dingya SunDepartment of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, China. Electronic address: [email protected]Xin LiHunan key laboratory of the research and development of novel pharmaceutical preparations, Changsha Medical University, Changsha, China. Electronic address: [email protected]Shengdan NieOffice of Drug Clinical Trial Organization, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China. Electronic address: [email protected]Jiajia LiuDepartment of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, China. Electronic address: [email protected]Shan WangDepartment of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, China. Electronic address: [email protected]

2022en

ABI

Аннотация

Abnormal energy metabolism, as one of the important hallmarks of cancer, was induced by multiple carcinogenic factors and tumor-specific microenvironments. It comprises aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis. Considering that metabolic reprogramming provides various nutrients for tumor survival and development, it has been considered a potential target for cancer therapy. Cannabinoids have been shown to exhibit a variety of anticancer activities by unclear mechanisms. This paper first reviews the recent progress of related signaling pathways (reactive oxygen species (ROS), AMP-activated protein kinase (AMPK), mitogen-activated protein kinases (MAPK), phosphoinositide 3-kinase (PI3K), hypoxia-inducible factor-1alpha (HIF-1α), and p53) mediating the reprogramming of cancer metabolism (including glucose metabolism, lipid metabolism, and amino acid metabolism). Then we comprehensively explore the latest discoveries and possible mechanisms of the anticancer effects of cannabinoids through the regulation of the above-mentioned related signaling pathways, to provide new targets and insights for cancer prevention and treatment.

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Идентификаторы

DOI: 10.1016/j.biopha.2022.113993

Цитирования и источники

Цитирований: 9Использованных источников: 0

Показатели — AkademScholar