Antifungal Diterpenoid Alkaloids from <i>Delphinium denudatum</i>
Atta‐ur RahmanH. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, Department of Chemistry, Cornell University, Ithaca, New York 14853-1301, and Department of Chemistry, The University of Calgary, Calgary, Alberta, Canada, T2N 1N4Amber NasreenH. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, Department of Chemistry, Cornell University, Ithaca, New York 14853-1301, and Department of Chemistry, The University of Calgary, Calgary, Alberta, Canada, T2N 1N4Farzana AkhtarH. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, Department of Chemistry, Cornell University, Ithaca, New York 14853-1301, and Department of Chemistry, The University of Calgary, Calgary, Alberta, Canada, T2N 1N4Mohammed Saleh ShekhaniH. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, Department of Chemistry, Cornell University, Ithaca, New York 14853-1301, and Department of Chemistry, The University of Calgary, Calgary, Alberta, Canada, T2N 1N4Jon ClardyH. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, Department of Chemistry, Cornell University, Ithaca, New York 14853-1301, and Department of Chemistry, The University of Calgary, Calgary, Alberta, Canada, T2N 1N4Masood ParvezH. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, Department of Chemistry, Cornell University, Ithaca, New York 14853-1301, and Department of Chemistry, The University of Calgary, Calgary, Alberta, Canada, T2N 1N4M. Iqbal ChoudharyH. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan, Department of Chemistry, Cornell University, Ithaca, New York 14853-1301, and Department of Chemistry, The University of Calgary, Calgary, Alberta, Canada, T2N 1N4
1997en
ABI
Аннотация
The roots of Delphinium denudatum have yielded a new diterpenoid alkaloid, 8-acetylheterophyllisine (1), in addition to the known alkaloids vilmorrianone (2), panicutine (3), denudatine (4), isotalatizidine (5), and condelphine (6), as well as 3-hydroxy-2-methyl-4H-pyran-4-one (7). Compounds 1, 3, and 7 have not been isolated from this plant previously. The structures of compounds 1, 3, and 7 were determined through spectral and X-ray diffraction analyses. Compounds 1-3 have shown antifungal activity against a number of human pathogenic fungi.
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