Low cerebral blood flow velocity and risk of white matter hyperintensities
Christophe TzourioINSERM (National Institute for Health and Medical Research) U360, Hôpital Pitié-Salpêtrière, Paris, FranceClaude LévyDepartment of Radiology Institut hospitalier Jacques Cartier, Massy, FranceCarole DufouilINSERM (National Institute for Health and Medical Research) U360, Hôpital Pitié-Salpêtrière, Paris, FrancePierre‐Jean TouboulDepartment of Neurology Hôpital Lariboisière, Paris, FrancePierre DucimetièreINSERM U258, Hôpital Paul Brousse, Villejuif, FranceAnnick AlpérovitchINSERM (National Institute for Health and Medical Research) U360, Hôpital Pitié‐Salpêtrière, Paris, France
2001en
ABI
Аннотация
Cerebral blood flow velocity (CBF-V) measured by transcranial doppler was assessed in 628 elderly individuals who had cerebral magnetic resonance imaging performed as part of a population-based study on vascular aging. Cerebral white matter hyperintensities (WMHs) were associated with low CBF-V, such as the adjusted odds ratios of severe WMHs from highest (referent) to lowest quartile of mean CBF-V were 1.0, 1.7, 3.7, and 4.3 (p = 0.001). Further, CBF-V was found to be a stronger risk factor for WMHs than high blood pressure. These findings suggest that the assessment of CBF-V might be a powerful tool in future studies on WMHs.
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