Обзорная статья

Consensus Proposals for a Unified System of Nomenclature of Hepatitis C Virus Genotypes *

Peter SimmondsCentre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh, United Kingdom. [email protected]Jens BukhHepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MDChristophe CombetInstitut de Biologie et Chimie des Protéines, Pôle BIoinformatique de Lyon, BioSciences Lyon-Gerland, Lyon, FranceGilbert DeléageInstitut de Biologie et Chimie des Protéines, Pôle BIoinformatique de Lyon, BioSciences Lyon-Gerland, Lyon, FranceNobuyuki EnomotoFirst Department of Internal Medicine, University of Yamanashi, Tamaho, Yamanashi, JapanStephen M. FeinstoneLaboratory of Hepatitis Viruses, Division of Viral Products, Food and Drug Administration, Bethesda, MDP. HalfonLaboratoire Alphabio, Marseille, FranceGeneviève InchauspéCNRS-BioMérieux, Immunothérapie des Maladies Infectieuses Chroniques, Lyon, FranceCarla KuikenTheoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NMGeert MaertensInnogenetics n.v., Ghent, BelgiumMasashi MizokamiDepartment of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, JapanDonald G. MurphyLaboratoire de Santé Publique du Québec, Institut National de Santé Publique du Québec, Québec, CanadaHiroaki OkamotoDivision of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi, JapanJean–Michel PawlotskyDepartment of Virology, INSERM U635, Henri Mondor Hospital, University of Paris, Créteil, FranceFrançois PéninInstitut de Biologie et Chimie des Protéines, Pôle BIoinformatique de Lyon, BioSciences Lyon-Gerland, Lyon, FranceErwin SablonInnogenetics n.v., Ghent, BelgiumTadasu Shin‐IDepartment of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya, JapanLieven StuyverHeinz‐Jürgen ThielInstitut für Virologie, Justus-Liebig-Universität, Giessen, GermanySergei ViazovInstitute of Virology, Essen University Hospital, Essen, GermanyAmy J. WeinerAnders WidellDepartment of Medical Microbiology, Malmö University Hospital, Lund University, Malmö, Sweden

2005en

ABI

Аннотация

International standardization and coordination of the nomenclature of variants of hepatitis C virus (HCV) is increasingly needed as more is discovered about the scale of HCV-related liver disease and important biological and antigenic differences that exist between variants. A group of scientists expert in the field of HCV genetic variability, and those involved in development of HCV sequence databases, the Hepatitis Virus Database (Japan), euHCVdb (France), and Los Alamos (United States), met to re-examine the status of HCV genotype nomenclature, resolve conflicting genotype or subtype names among described variants of HCV, and draw up revised criteria for the assignment of new genotypes as they are discovered in the future. A comprehensive listing of all currently classified variants of HCV incorporates a number of agreed genotype and subtype name re-assignments to create consistency in nomenclature. The paper also contains consensus proposals for the classification of new variants into genotypes and subtypes, which recognizes and incorporates new knowledge of HCV genetic diversity and epidemiology. A proposal was made that HCV variants be classified into 6 genotypes (representing the 6 genetic groups defined by phylogenetic analysis). Subtype name assignment will be either confirmed or provisional, depending on the availability of complete or partial nucleotide sequence data, or remain unassigned where fewer than 3 examples of a new subtype have been described. In conclusion, these proposals provide the framework by which the HCV databases store and provide access to data on HCV, which will internationally coordinate the assignment of new genotypes and subtypes in the future.

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Идентификаторы

DOI: 10.1002/hep.20819

Цитирования и источники

Цитирований: 2Использованных источников: 0

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