Статья

Hepatitis C databases, principles and utility to researchers

Carla KuikenTheoretical Biology and Biophysics group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. [email protected]Masashi MizokamiDepartment of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences — Kawasumi Mizuho Nagoya, JapanGilbert DeléageInstitut de Biologie et Chimie des Protéines —UMR5086 CNRS/UCBL - IFR128 BioSciences Lyon-Gerland - 7, Lyon, FranceKarina YusimTheoretical Biology and Biophysics group, Los Alamos National Laboratory, Los Alamos, NMFrançois PéninInstitut de Biologie et Chimie des Protéines —UMR5086 CNRS/UCBL - IFR128 BioSciences Lyon-Gerland - 7, Lyon, FranceTadasu Shin-IDepartment of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences — Kawasumi Mizuho Nagoya, JapanCéline CharavayInstitut de Biologie et Chimie des Protéines —UMR5086 CNRS/UCBL - IFR128 BioSciences Lyon-Gerland - 7, Lyon, FranceNing TaoTheoretical Biology and Biophysics group, Los Alamos National Laboratory, Los Alamos, NMD. CrisanInstitut de Biologie et de Chimie des ProtéinesDelphine GrandoInstitut de Biologie et Chimie des Protéines —UMR5086 CNRS/UCBL - IFR128 BioSciences Lyon-Gerland - 7, Lyon, FranceAnita DalwaniTheoretical Biology and Biophysics group, Los Alamos National Laboratory, Los Alamos, NMC. GeourjonInstitut de Biologie et Chimie des Protéines —UMR5086 CNRS/UCBL - IFR128 BioSciences Lyon-Gerland - 7, Lyon, FranceAshish Sunil AgrawalTheoretical Biology and Biophysics group, Los Alamos National Laboratory, Los Alamos, NMChristophe CombetInstitut de Biologie et Chimie des Protéines —UMR5086 CNRS/UCBL - IFR128 BioSciences Lyon-Gerland - 7, Lyon, France

2006en

ABI

Аннотация

Part of the effort to develop hepatitis C-specific drugs a nd vaccines is the study of genetic variability of allpublicly available HCV sequences. Three HCV databases are currently available to aid this effort and to provide additional insight into the basic biology, immunology, and evolution of the virus. The Japanese HCV database (http://s2as02.genes.nig.ac.jp) gives access to a genomic mapping of sequences as well as their phylogenetic relationships. The European HCV database (http://euhcvdb.ibcp.fr) offers access to a computer-annotated set of sequences and molecular models of HCV proteins and focuses on protein sequence, structure and function analysis. The HCV database at the Los Alamos National Laboratory in the United States (http://hcv.lanl.gov) provides access to a manually annotated sequence database and a database of immunological epitopes which contains concise descriptions of experimental results. In this paper, we briefly describe each of these databases and their associated websites and tools, and give some examples of their use in furthering HCV research.

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Идентификаторы

DOI: 10.1002/hep.21162

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar