Conformation of the tridimensional structure of 1,2,3,4,6‐pentagalloyl‐β‐D‐glucopyranose (PGG) by <sup>1</sup>H NMR, NOESY and theoretical study and membrane interaction in a simulated phospholipid bilayer: a first insight
Giangiacomo BerettaDepartment of Pharmaceutical Sciences 'Pietro Pratesi', Faculty of Pharmacy, University of Milan, Italy. [email protected]Roberto ArtaliDepartment of Pharmaceutical Sciences ‘Pietro Pratesi’, Faculty of Pharmacy, University of Milan, Milan, ItalyEnrico CanevaCentro Interdipartimentale Grandi Strumentazioni, University of Milan, Milan, ItalyRoberto Maffei FacinoDepartment of Pharmaceutical Sciences ‘Pietro Pratesi’, Faculty of Pharmacy, University of Milan, Milan, Italy
2011en
ABI
Аннотация
1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose (PGG) is a polyphenolic compound found in substantial amounts in a number of medicinal herbs. We report (i) its conformational analysis by solution NMR and molecular dynamics calculation and (ii) theoretical study of its interaction with a model membrane bilayer. The galloyl groups B and E appear to play important roles in the interaction with the phospholipid bilayer.
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