Aluminum Nanoparticles as Substrates for Metal-Enhanced Fluorescence in the Ultraviolet for the Label-Free Detection of Biomolecules
Mustafa Habib ChowdhuryCenter for Fluorescence Spectroscopy, Medical Biotechnology Center, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, Illinois 60439, and Lumerical Solutions Inc., 201-1290 Homer Street, Vancouver, British Columbia V6B 2Y5, CanadaKrishanu RayCenter for Fluorescence Spectroscopy, Medical Biotechnology Center, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, Illinois 60439, and Lumerical Solutions Inc., 201-1290 Homer Street, Vancouver, British Columbia V6B 2Y5, CanadaStephen K. GrayCenter for Fluorescence Spectroscopy, Medical Biotechnology Center, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, Illinois 60439, and Lumerical Solutions Inc., 201-1290 Homer Street, Vancouver, British Columbia V6B 2Y5, CanadaJames PondCenter for Fluorescence Spectroscopy, Medical Biotechnology Center, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, Illinois 60439, and Lumerical Solutions Inc., 201-1290 Homer Street, Vancouver, British Columbia V6B 2Y5, CanadaJoseph R. LakowiczCenter for Fluorescence Spectroscopy, Medical Biotechnology Center, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, Illinois 60439, and Lumerical Solutions Inc., 201-1290 Homer Street, Vancouver, British Columbia V6B 2Y5, Canada
2009en
ABI
Аннотация
We use finite-difference time-domain calculations to show that aluminum nanoparticles are efficient substrates for metal-enhanced fluorescence (MEF) in the ultraviolet (UV) for the label-free detection of biomolecules. The radiated power enhancement of the fluorophores in proximity to aluminum nanoparticles is strongly dependent on the nanoparticle size, fluorophore-nanoparticle spacing, and fluorophore orientation. Additionally, the enhancement is dramatically increased when the fluorophore is between two aluminum nanoparticles of a dimer. Finally, we present experimental evidence that functionalized forms of amino acids tryptophan and tyrosine exhibit MEF when spin-coated onto aluminum nanostructures.
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