Plasma Double-peak Phenomenon Following Oral Administration

The plasma concentration-time curves of many drugs often show a double-peak or mutiple-peak phenomenon after oral administration.The non-uniformly rate of drug disintegrate and release from the dosage form and lipid solubility may be the common causes of this matter.Enterohepatic circulation and gastric pH were thought to be the two main factors for the double-peak phenomenon from Physiology Perspective.According to the lasted report,there were multiple mechanism of double-peak phenomenon and the greater part of them have been controversial,mainly include that gastricmotility,multiple gastrointestinal tract absorption site,uneven distribution of P-glycoprotein in gut and so on.The main purpose of the article is summarizing the research situation of the mechanism of this phenomenon to provide reference for clinical safe drug use.

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