Three Tyrosinase Inhibitors and Antioxidant Compounds from <i>Salsola foetida</i>
Khalid Mohammed KhanH.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan (phone: (92-21)-9243224, 9243211Ghulam M. Maharvifax: (92-21)-9243190-91)Ahmed Abbaskhanfax: (92-21)-9243190-91)Safdar HayatH.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan (phone: (92-21)-9243224, 9243211Mahmud Tareq Hassan Khanfax: (92-21)-9243190-91)Talat MakhmoorH.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan (phone: (92-21)-9243224, 9243211M. Iqbal Choudharyfax: (92-21)-9243190-91)Farzana ShaheenH.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan (phone: (92-21)-9243224, 9243211Atta‐ur RahmanH.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan (phone: (92-21)-9243224, 9243211
2003en
ABI
Аннотация
Abstract Phytochemical investigation on the whole plant of Salsola foetida resulted in the isolation of three new phenolic compounds 1, 2 , and 3 , which exhibit tyrosinase inhibition with moderate antioxidant activity. Compounds 1 – 3 inhibited tyrosinase with IC 50 2.61, 1.85, and 0.40 μ M , while exhibiting DPPH radical scavenging activity with IC 50 383, 427 and 378 μ M , respectively. The structures of 1, 2 , and 3 were determined by modern spectroscopic techniques.
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