Статья

Tyrosinase Inhibitors from Rhododendron collettianum and Their Structure-Activity Relationship (SAR) Studies

Viqar Uddin AhmadH.E.J. Research Institute of Chemistry, University of KarachiFarman UllahH.E.J. Research Institute of Chemistry, University of KarachiJavid HussainH.E.J. Research Institute of Chemistry, University of KarachiUmar FarooqH.E.J. Research Institute of Chemistry, University of KarachiMuhammad ZubaırH.E.J. Research Institute of Chemistry, University of KarachiMahmud Tareq Hassan KhanH.E.J. Research Institute of Chemistry, University of KarachiM. Iqbal ChoudharyH.E.J. Research Institute of Chemistry, University of Karachi

2004en

ABI

Аннотация

A new coumarinolignoid 8'-epi-cleomiscosin A (1) together with the new glycoside 8-O-beta-D-glucopyranosyl-6-hydroxy-2-methyl-4H-1-benzopyrane-4-one (2) have been isolated from the aerial parts of Rhododendron collettianum and their structures determined on the basis of spectroscopic evidences. Tyrosinase inhibition study of these compounds and their structure-activity relationship (SAR) were also investigated. The compounds exhibited potent to mild inhibition activity against the enzyme. Especially, the compound 1 showed strong inhibition (IC50=1.33 microM) against the enzyme tyrosinase, as compared to the standard tyrosinase inhibitors kojic acid (IC50=16.67 microM) and L-mimosine (IC50=3.68 microM), indicating its potential used for the treatment of hyperpigmentation associated with the high production of melanocytes.

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Идентификаторы

DOI: 10.1248/cpb.52.1458

Цитирования и источники

Цитирований: 3Использованных источников: 0

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