Tyrosinase-Inhibitory Long-Chain Esters from Amberboa ramosa
Sher Bahadar KhanInternational Center for Chemical Sciences, H.E.J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of KarachiAzhar-ul-HaqInternational Center for Chemical Sciences, H.E.J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of KarachiNighat AfzaPharmaceutical Research Centre, PCSIR Laboratories-Complex KarachiAbdul MalikInternational Center for Chemical Sciences, H.E.J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of KarachiMahmud KhanInternational Center for Chemical Sciences, H.E.J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of KarachiMuhammad Raza ShahInternational Center for Chemical Sciences, H.E.J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of KarachiM. Iqbal ChoudharyInternational Center for Chemical Sciences, H.E.J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi
2005en
ABI
Аннотация
Long-chain esters 1 and 2 have been isolated from the chloroform-soluble fraction of Amberboa ramosa and their structures assigned to be methyl 2beta(2S)-hydroxyl-7(E)-tritriacontenoate (1) and methyl 2beta(2S)-O-beta-D-galactopyranosyl-7(E)-tetratriacontenoate (2). In addition, tricontane (3) and apigenin (4) are also reported for the first time from this species. The structures were assigned on the basis of 1D and 2D NMR techniques. Compounds 1 and 2 showed strong to moderate inhibitory activity against tyrosinase.
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