Staurosporine Induces Apoptotic Volume Decrease (AVD) in ECV304 Cells
Anna Maria PorcelliDipartimento di Biologia Ev. Sp., Dipartimento di Fisiologia Umana e Generale, Universita di Bologna, 40126 Bologna, Italy. [email protected]Anna GhelliDipartimento di Biologia Ev. Sp., Universita di Bologna, 40126 Bologna, ItalyClaudia ZannaDipartimento di Biologia Ev. Sp., Universita di Bologna, 40126 Bologna, ItalyPiera ValenteDipartimento di Fisiologia Umana e Generale, Universita di Bologna, 40126 Bologna, ItalyStefano FerroniDipartimento di Fisiologia Umana e Generale, Universita di Bologna, 40126 Bologna, ItalyMichela RugoloDipartimento di Biologia Ev. Sp., Universita di Bologna, 40126 Bologna, Italy
2003en
ABI
Аннотация
Incubation of ECV304 cells with 1 micro M staurosporine (STS) causes apoptotic cell death. In the present study, we investigate whether a significant apoptotic volume decrease (AVD) was apparent during the very early times (1 h) of the apoptotic process. Our data suggest that upregulation of Cl(-) (and possibly K(+)) channels by STS may be a very early primary event required for the subsequent onset of AVD, which results in apoptosis.
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