Статья

High Prevalence of Multidrug-Resistant Tuberculosis, Swaziland, 2009–2010

Elisabeth Sánchez-PadillaEpicentre, Paris, France. [email protected]Themba DlaminiEpicentre, Paris, FranceAlexandra Ascorraand Médecins Sans Frontières, Geneva, SwitzerlandSabine Rüsch–Gerdesand Médecins Sans Frontières, Geneva, SwitzerlandZerihun Demissie TeferaNational Tuberculosis Control Programme, Mbabane, Swaziland (T. Dlamini);Philippe CalainNational Reference Center for Mycobacteria, Borstel, GermanyRoberto de la Tourand Médecins Sans Frontières, Geneva, SwitzerlandFrauke JochimsEpicentre, Paris, FranceElvira RichterNational Reference Center for Mycobacteria, Borstel, GermanyMaryline BonnetNational Tuberculosis Control Programme, Mbabane, Swaziland (T. Dlamini);

2012en

ABI

Аннотация

In Africa, although emergence of multidrug-resistant (MDR) tuberculosis (TB) represents a serious threat in countries severely affected by the HIV epidemic, most countries lack drug-resistant TB data. This finding was particularly true in the Kingdom of Swaziland, which has the world's highest HIV and TB prevalences. Therefore, we conducted a national survey in 2009-2010 to measure prevalence of drug-resistant TB. Of 988 patients screened, 420 new case-patients and 420 previously treated case-patients met the study criteria. Among culture-positive patients, 15.3% new case-patients and 49.5% previously treated case-patients harbored drug-resistant strains. MDR TB prevalence was 7.7% and 33.8% among new case-patients and previously treated case-patients, respectively. HIV infection and past TB treatment were independently associated with MDR TB. The findings assert the need for wide-scale intervention in resource-limited contexts such as Swaziland, where diagnostic and treatment facilities and health personnel are lacking.

Перевод пока недоступен

Идентификаторы

DOI: 10.3201/eid1801.110850

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar