Inhibition of HIV-1 Integrase by Galloyl Glucoses from Terminalia chebula and Flavonol Glycoside Gallates from Euphorbia pekinensis
Mi‐Jeong AhnCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, KoreaChul Young KimCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, KoreaJi Suk LeeCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, KoreaTae Gyun KimNational Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, KoreaSeung Hee KimNational Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, KoreaChong-Kyo LeeKorean Research Institute of Chemical Technology (KRICT), Taejon, KoreaBo-Bin LeeDepartment of Biotechnology, Chung-Ang University, Anseong, Kyungki-Do, KoreaCha‐Gyun ShinDepartment of Biotechnology, Chung-Ang University, Anseong, Kyungki-Do, KoreaHoon HuhCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, KoreaJinwoong KimCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea
2002en
ABI
Аннотация
The bioassay-directed isolation of Terminalia chebula fruits afforded four human immunodeficiency virus type 1 (HIV-1) integrase inhibitors, gallic acid ( 1) and three galloyl glucoses ( 2 - 4). In addition, four flavonol glycoside gallates ( 5 - 8) from Euphorbia pekinensis containing the galloyl moiety also showed the inhibitory activity at a level comparable to those of 2 - 4. By comparison with the activities of the compounds not bearing this moiety, it is proposed that the galloyl moiety plays a major role for inhibition against the 3'-processing of HIV-1 integrase of these compounds.
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