Статья

Cancer‐Cell‐Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors

Huiping SunSchool of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 ChinaJinghan SuState Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica, Chinese Academy of Sciences 501 Haike Road Shanghai 201203 ChinaQingshuo MengState Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica, Chinese Academy of Sciences 501 Haike Road Shanghai 201203 ChinaQi YinState Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica, Chinese Academy of Sciences 501 Haike Road Shanghai 201203 ChinaLingli ChenState Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica, Chinese Academy of Sciences 501 Haike Road Shanghai 201203 ChinaWangwen GuState Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica, Chinese Academy of Sciences 501 Haike Road Shanghai 201203 ChinaPengcheng ZhangState Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica, Chinese Academy of Sciences 501 Haike Road Shanghai 201203 ChinaZhiwen ZhangState Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica, Chinese Academy of Sciences 501 Haike Road Shanghai 201203 ChinaHaijun YuState Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica, Chinese Academy of Sciences 501 Haike Road Shanghai 201203 ChinaSiling WangSchool of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 ChinaYaping LiState Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica, Chinese Academy of Sciences 501 Haike Road Shanghai 201203 China

2016en

ABI

Аннотация

A unique biomimetic drug-delivery system composed of 4T1-breast-cancer-cell membranes and paclitaxel-loaded polymeric nanoparticles (PPNs) (cell-membrane-coated PPNs), demonstrates superior interactions to its source tumor cells and elongated blood circulation, and displays highly cell-specific targeting of the homotypic primary tumor and metastases, with successful inhibition of the growth and lung metastasis of the breast cancer cells. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Перевод пока недоступен

Идентификаторы

DOI: 10.1002/adma.201602173

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar