Phytoecdysteroids Increase Protein Synthesis in Skeletal Muscle Cells
Jonathan Gorelick-FeldmanBiotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey 08901;Hallett Center for Diabetes and Endocrinology, Brown Medical School, Providence, Rhode Island 02912; and Department of Natural Resources and Environmental Sciences, University ofIllinois, Urbana, Illinois 61801David B. MacLeanBiotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey 08901;Hallett Center for Diabetes and Endocrinology, Brown Medical School, Providence, Rhode Island 02912; and Department of Natural Resources and Environmental Sciences, University ofIllinois, Urbana, Illinois 61801Nebojša IlićBiotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey 08901;Hallett Center for Diabetes and Endocrinology, Brown Medical School, Providence, Rhode Island 02912; and Department of Natural Resources and Environmental Sciences, University ofIllinois, Urbana, Illinois 61801Alexander PoulevBiotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey 08901;Hallett Center for Diabetes and Endocrinology, Brown Medical School, Providence, Rhode Island 02912; and Department of Natural Resources and Environmental Sciences, University ofIllinois, Urbana, Illinois 61801Mary Ann LilaBiotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey 08901;Hallett Center for Diabetes and Endocrinology, Brown Medical School, Providence, Rhode Island 02912; and Department of Natural Resources and Environmental Sciences, University ofIllinois, Urbana, Illinois 61801Diana M. ChengBiotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey 08901;Hallett Center for Diabetes and Endocrinology, Brown Medical School, Providence, Rhode Island 02912; and Department of Natural Resources and Environmental Sciences, University ofIllinois, Urbana, Illinois 61801Ilya RaskinBiotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey 08901;Hallett Center for Diabetes and Endocrinology, Brown Medical School, Providence, Rhode Island 02912; and Department of Natural Resources and Environmental Sciences, University ofIllinois, Urbana, Illinois 61801
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Аннотация
Phytoecdysteroids, which are structurally similar or identical to insect molting hormones, produce a range of effects in mammals, including increasing growth and physical performance. To study the mechanism of action of phytoecdysteroids in mammalian tissue, an in vitro cellular assay of protein synthesis was developed. In C2C12 murine myotubes and human primary myotubes, phytoecdysteroids increased protein synthesis by up to 20%. In vivo, ecdysteroids increased rat grip strength. Ecdysteroid-containing plant extracts produced similar results. The effect was inhibited by a phosphoinositide kinase-3 inhibitor, which suggests a PI3K-mediated mechanism.
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