Статья

A new antioxidant flavone glycoside from <i>Scutellaria baicalensis</i> Georgi

Meng-Hua WangDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, 639 Longmian Avenue, Nanjing211198, P.R. ChinaLin-Zhen LiDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, 639 Longmian Avenue, Nanjing211198, P.R. ChinaJianbo SunDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, 639 Longmian Avenue, Nanjing211198, P.R. ChinaFeihua WuDepartment of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing210009, P.R. ChinaJingyu LiangDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, 639 Longmian Avenue, Nanjing211198, P.R. China

2014en

ABI

Аннотация

A new flavone glycoside, wogonin 7-O-β-D-ethylglucuronide (1), together with a new natural flavone glycoside baicalein 7-O-β-D-ethylglucuronide (2) and four known analogues, wogonoside (3), wogonin (4), oroxylin A 7-O-β-D-methylglucuronide (5) and oroxylin A (6), was isolated from the roots of Scutellaria baicalensis Georgi. The structure elucidation of the new compound was primarily based on HR-ESI-MS, 1D and 2D NMR analyses. Compounds 1 and 3 inhibited FeSO4-Cys-induced liver homogenate lipid peroxidation with IC50 at 18.2 μM and 24.9 μM, respectively, and exhibited strong cytoprotective effects against H2O2-induced oxidative damage in human umbilical vein endothelial cells at low concentrations of 10.0 μM and 3.0 μM.

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Идентификаторы

DOI: 10.1080/14786419.2014.931391

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar