The Isolation of Two New Fungal Inhibitors of<sup>35</sup>S-TBPS Binding to the Brain GABA<sub>A</sub>/benzodiazepine chloride Channel Receptor Complex
R. ShanDivision of Organic Chemistry 2, Chemical Center, University of Lund , P.O.B. 124, S-221 00, Lund, SwedenHeidrun AnkeLB Biotechnologie, University of Kaiserslautern , Paul Ehrlich-str. 23, D-67663, Kaiserslautern, GermanyMogens Brøndsted NielsenDepartment of Biochemistry , Sct. Hans Hospital , DK-4000, Roskilde, DenmarkOlov SternerDivision of Organic Chemistry 2, Chemical Center, University of Lund , P.O.B. 124, S-221 00, Lund, SwedenM R WittDepartment of Biochemistry , Sct. Hans Hospital , DK-4000, Roskilde, Denmark
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Аннотация
Abstract Bioassay-guided fractionation of the ethyl acetate extracts of the culture filtrate of the fungal culture HA 137–89 yielded the two salicylic acid derivatives 1 and 2, as inhibitors of the binding of 35S-TBPS to the GABAA/benzodiazepine chloride channel receptor complex in vitro. Their structures were determined by spectroscopic and chemical methods.
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