SARS-CoV-2 viral load is associated with increased disease severity and mortality
Jesse FajnzylberBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USAJames ReganBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USAKendyll CoxenBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USAHeather CorryBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USAColline WongBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USAAlexandra RosenthalBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USADaniel WorrallRagon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, MA, USAFrançoise GiguelMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAAlicja Piechocka‐TrochaRagon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, MA, USACaroline AtyeoRagon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, MA, USAStephanie FischingerRagon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, MA, USAAndrew T. ChanMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAKeith T. FlahertyMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAKathryn HallMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAMichael DouganMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAEdward T. RyanMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAElizabeth GillespieBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USARida ChishtiBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USAYijia LiBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USANikolaus JilgBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USADusan HanidziarMassachusetts General Hospital, Harvard Medical School, Boston, MA, USARebecca M. BaronBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USALindsey R. BadenBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USAAthe TsibrisBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USAKatrina ArmstrongMassachusetts General Hospital, Harvard Medical School, Boston, MA, USADaniel R. KuritzkesBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USAGalit AlterMassachusetts General Hospital, Harvard Medical School, Boston, MA, USABruce D. WalkerHoward Hughes Medical Institute, Chevy Chase, MD, USAXu G. YuMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAJonathan Z. LiBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. [email protected]Betelihem A. AbaynehPatrick AllenMassachusetts General Hospital, Harvard Medical School, Boston, MA, USADiane AntilleMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAAlejandro B. BalazsMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAJulia BalsMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAMax BarbashMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAYannic C. BartschMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAJulie BoucauMassachusetts General Hospital, Harvard Medical School, Boston, MA, USASiobhan BoyceMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAJoan BraleyMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAKaren BranchMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAKatherine BroderickMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAJulia CarneyMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAJoshua M ChevalierMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAManish C. ChoudharyBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USANavin ChowdhuryMassachusetts General Hospital, Harvard Medical School, Boston, MA, USATrevor CordwellBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAGeorge Q. DaleyHarvard Medical School, Boston, MA, USASusan DavidsonMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAMichaël DesjardinsBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USALauren DonahueBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USADavid A. DrewMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAKevin EinkaufMassachusetts General Hospital, Harvard Medical School, Boston, MA, USASampson ElizabethBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAAshley EllimanMassachusetts General Hospital, Harvard Medical School, Boston, MA, USABehzad EtemadBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAJon FallonMassachusetts General Hospital, Harvard Medical School, Boston, MA, USALiz FedirkoMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAKelsey FinnMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAJeanne FlanneryMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAPamela J. FordeMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAPilar García‐BroncanoMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAElise GettingsMassachusetts General Hospital, Harvard Medical School, Boston, MA, USADavid GolanHarvard Medical School, Boston, MA, USAKirsten GoodmanBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAAmanda GriffinMassachusetts General Hospital, Harvard Medical School, Boston, MA, USASheila GrimmelMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAKathleen GrinkeMassachusetts General Hospital, Harvard Medical School, Boston, MA, USACiputra Adijaya HartanaMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAMeg HealyMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAHoward M. HellerHarvard Medical School, Boston, MA, USADeborah HenaultMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAGrace HollandMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAChenyang JiangMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAHannah JordanBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAPaulina KapłonekMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAElizabeth W. KarlsonBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAMarshall KarpellMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAChantal KayitesiMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAEvan C. LamMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAVlasta LaValleMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAKristina LefteriMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAXiaodong LianMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAMathias LichterfeldBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USADaniel LingwoodMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAHang LiuMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAJin-Qing LiuMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAK. A. J. LopezBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAYuting LuMassachusetts General Hospital, Harvard Medical School, Boston, MA, USASarah LuthernMassachusetts General Hospital, Harvard Medical School, Boston, MA, USANgoc L. LyMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAMaureen MacGowanBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAKaren MagispocBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAJordan MarchewkaMassachusetts General Hospital, Harvard Medical School, Boston, MA, USABrittani MartinoMassachusetts General Hospital, Harvard Medical School, Boston, MA, USARoseann McNamaraMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAAshlin R. MichellMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAIlan MillstromMassachusetts General Hospital, Harvard Medical School, Boston, MA, USANoah MirandaMassachusetts General Hospital, Harvard Medical School, Boston, MA, USAChristian NambuMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA
2020en
ABI
Аннотация
The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease 2019 (COVID-19). Here, we quantify SARS-CoV-2 viral load from participants with a diverse range of COVID-19 disease severity, including those requiring hospitalization, outpatients with mild disease, and individuals with resolved infection. We detected SARS-CoV-2 plasma RNA in 27% of hospitalized participants, and 13% of outpatients diagnosed with COVID-19. Amongst the participants hospitalized with COVID-19, we report that a higher prevalence of detectable SARS-CoV-2 plasma viral load is associated with worse respiratory disease severity, lower absolute lymphocyte counts, and increased markers of inflammation, including C-reactive protein and IL-6. SARS-CoV-2 viral loads, especially plasma viremia, are associated with increased risk of mortality. Our data show that SARS-CoV-2 viral loads may aid in the risk stratification of patients with COVID-19, and therefore its role in disease pathogenesis should be further explored.
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