Статья

Polyketides and Terpenoids with Potent Antibacterial Activities from the<i>Artemisia argyi</i>‐Derived Fungus<i>Trichoderma koningiopsis</i>QA‐3

Xiaoshan ShiCollege of Chemistry and Chemical Engineering Hubei Normal University Cihu Road 11 Huangshi 435002 P. R. ChinaLing‐Hong MengKey Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences and Laboratory of Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology Nanhai Road 7 Qingdao 266071 P. R. ChinaXin LiCenter for Ocean Mega-Science Chinese Academy of Sciences Nanhai Road 7 Qingdao 266071 P. R. ChinaXin LiCenter for Ocean Mega-Science Chinese Academy of Sciences Nanhai Road 7 Qingdao 266071 P. R. ChinaDunjia WangCollege of Chemistry and Chemical Engineering Hubei Normal University Cihu Road 11 Huangshi 435002 P. R. ChinaXingwang ZhouCollege of Chemistry and Chemical Engineering Hubei Normal University Cihu Road 11 Huangshi 435002 P. R. ChinaFeng‐Yu DuCollege of Chemistry and Pharmacy Qingdao Agricultural University Changcheng Road 700 Qingdao 266109 P. R. ChinaBin‐Gui WangCenter for Ocean Mega-Science Chinese Academy of Sciences Nanhai Road 7 Qingdao 266071 P. R. ChinaXiao‐Ming LiCenter for Ocean Mega-Science Chinese Academy of Sciences Nanhai Road 7 Qingdao 266071 P. R. China

2020en

ABI

Аннотация

The AcOEt extract of Artemisia argyi-derived fungus Trichoderma koningiopsis QA-3 showed potent inhibitory activity against pathogenic bacteria. Fractionation of the extract resulted in the isolation of three new polyketides (1-3) and two new terpenoids (4 and 5), together with three known metabolites (6-8). Their chemical structures were analyzed by NMR spectra, ECD, HR-ESI-MS or HR-EI-MS, optical rotation, and X-ray crystallographic data, as well as by comparison with literature reports. In the antibacterial assays, 3-hydroxyharziandione (4) showed potent activity against human pathogen Escherichia coli with an MIC value of 0.5 μg/mL, while 6-(3-hydroxypent-1-en-1-yl)-2H-pyran-2-one exhibited strong activity against marine-derived aquatic pathogen Micrococcus luteus with an MIC value of 1.0 μg/mL.

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Идентификаторы

DOI: 10.1002/cbdv.202000566

Цитирования и источники

Цитирований: 2Использованных источников: 0

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