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Influenza A (H<sub>1</sub>N<sub>1</sub>) Antiviral and Cytotoxic Agents from <i>Ferula assa-foetida</i>

Chia-Lin LeeGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, Department of Microbiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan, Republic of China, and Chemistry of Natural Products Department, National Research Center, Cairo, 12622, EgyptLien-Chai ChiangGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, Department of Microbiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan, Republic of China, and Chemistry of Natural Products Department, National Research Center, Cairo, 12622, EgyptLi-Hung ChengChina Medical UniversityChih‐Chuang LiawGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, Department of Microbiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan, Republic of China, and Chemistry of Natural Products Department, National Research Center, Cairo, 12622, EgyptMohamed H. Abd El‐RazekGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, Department of Microbiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan, Republic of China, and Chemistry of Natural Products Department, National Research Center, Cairo, 12622, EgyptFang‐Rong ChangGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, Department of Microbiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan, Republic of China, and Chemistry of Natural Products Department, National Research Center, Cairo, 12622, EgyptYang‐Chang WuGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, Department of Microbiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China, Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan, Republic of China, and Chemistry of Natural Products Department, National Research Center, Cairo, 12622, Egypt
2009en
ABI

Аннотация

Two new sesquiterpene coumarins, designated 5'-acetoxy-8'-hydroxyumbelliprenin (1) and 10'R-acetoxy-11'-hydroxyumbelliprenin (2), and a new diterpene, 15-hydroxy-6-en-dehydroabietic acid (3), along with 27 known compounds, were isolated from a CHCl(3)-soluble extract of Ferula assa-foetida through bioassay-guided fractionation. The structures of the new metabolites 1-3 were identified by spectroscopic data interpretation and by the Mosher ester method. Compounds 4 and 6-13 showed greater potency against influenza A virus (H(1)N(1)) (IC(50) 0.26-0.86 microg/mL) than amantadine (IC(50) 0.92 microg/mL), and 11 exhibited the best potency (IC(50) 0.51, 2.6, and 3.4 microg/mL) of these compounds against the HepG2, Hep3B, and MCF-7 cancer cell lines, respectively.

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Идентификаторы

DOI
10.1021/np900158f

Цитирования и источники

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