Vascular dysfunction—The disregarded partner of Alzheimer's disease
Melanie D. SweeneyDepartment of Physiology and Neuroscience Zilkha Neurogenetic Institute Keck School of Medicine University of Southern California Los Angeles CA USAAxel MontagneDepartment of Physiology and Neuroscience Zilkha Neurogenetic Institute Keck School of Medicine University of Southern California Los Angeles CA USAAbhay P. SagareDepartment of Physiology and Neuroscience Zilkha Neurogenetic Institute Keck School of Medicine University of Southern California Los Angeles CA USADaniel A. NationAlzheimer's Disease Research Center Keck School of Medicine at the University of Southern California Los Angeles CA USALon S. SchneiderAlzheimer's Disease Research Center Keck School of Medicine at the University of Southern California Los Angeles CA USAHelena C. ChuiAlzheimer's Disease Research Center Keck School of Medicine at the University of Southern California Los Angeles CA USAMichael G. HarringtonHuntington Medical Research Institutes Pasadena CA USAJudy PaLaboratory of Neuro Imaging (LONI) Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California Los Angeles CA USAMeng LawAlzheimer's Disease Research Center Keck School of Medicine at the University of Southern California Los Angeles CA USADanny J.J. WangLaboratory of Neuro Imaging (LONI) Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California Los Angeles CA USARussell E. JacobsDepartment of Physiology and Neuroscience Zilkha Neurogenetic Institute Keck School of Medicine University of Southern California Los Angeles CA USAFergus DoubalNeuroimaging Sciences and Brain Research Imaging Center Division of Neuroimaging Sciences Center for Clinical Brain Sciences UK Dementia Research Institute at the University of Edinburgh UKJoel RamirezHeart and Stroke Foundation Canadian Partnership for Stroke Recovery Sunnybrook Health Sciences Centre University of Toronto Toronto ON CanadaSandra E. BlackDepartment of Medicine (Neurology) Hurvitz Brain Sciences Program Canadian Partnership for Stroke Recovery and LC Campbell Cognitive Neurology Research Unit Sunnybrook Research Institute Sunnybrook Health Sciences Centre Toronto Dementia Research Alliance University of Toronto Toronto CanadaMaiken NedergaardDivision of Glia Disease and Therapeutics Center for Translational Neuromedicine University of Rochester Medical School Rochester NY USAHelene BenvenisteDepartment of Anesthesiology Yale School of Medicine New Haven CT USAMartin DichgansInstitute for Stroke and Dementia Research (ISD) Ludwing‐Maximilians‐University Munich Munich GermanyCostantino IadecolaFeil Family Brain and Mind Research Institute Weill Cornell Medicine New York NY USASeth LoveInstitute of Clinical Neurosciences University of Bristol School of Medicine Level 2 Learning and Research Southmead Hospital Bristol UKPhilip M. BathStroke Trials Unit Division of Clinical Neuroscience University of Nottingham City Hospital Campus Nottingham UKHugh S. MarkusStroke Research Group Department of Clinical Neurosciences University of Cambridge Cambridge Biomedical Campus Cambridge UKRustam Al‐Shahi SalmanNeuroimaging Sciences and Brain Research Imaging Center Division of Neuroimaging Sciences Center for Clinical Brain Sciences UK Dementia Research Institute at the University of Edinburgh UKStuart M. AllanFaculty of Biology, Medicine and Health Division of Neuroscience and Experimental Psychology School of Biological Sciences University of Manchester Manchester UKTerence J. QuinnInstitute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UKRajesh N. KalariaNeurovascular Research Group Institute of Neuroscience Newcastle University Newcastle upon Tyne UKDavid J. WerringStroke Research Centre Department of Brain Repair and Rehabilitation UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery London UKRoxana O. CarareFaculty of Medicine University of Southampton Southampton UKRhian M. TouyzBritish Heart Foundation, Glasgow Cardiovascular Research Centre Institute of Cardiovascular and Medical Sciences University of Glasgow UKSteven WilliamsDepartment of Neuroimaging Institute of Psychiatry Psychology & Neuroscience King's College London London UKMichael A. MoskowitzStroke and Neurovascular Regulation Laboratory Departments of Radiology and Neurology Harvard Medical School Massachusetts General Hospital Boston MA USAZvonimir S. KatušićDepartment of Anesthesiology and Molecular Pharmacology and Experimental Therapeutics Mayo Clinic College of Medicine Rochester MN USASarah E. LutzDepartment of Anatomy and Cell Biology University of Illinois at Chicago Chicago IL USAOrly LazarovDepartment of Anatomy and Cell Biology University of Illinois at Chicago Chicago IL USARichard D. MinshallDepartment of Anesthesiology University of Illinois at Chicago Chicago IL USAJalees RehmanDepartment of Medicine The Center for Lung and Vascular Biology The University of Illinois College of Medicine Chicago IL USAThomas P. DavisDepartment of Pharmacology University of Arizona Tucson AZ USACheryl L. WellingtonDepartment of Pathology and Laboratory Medicine Djavad Mowafaghian Centre for Brain Health University of British Columbia Vancouver British Columbia CanadaHector M. GonzálezDepartment of Neurosciences University of California San Diego CA USAChun YuanDepartment of Radiology University of Washington Seattle WA USASamuel N. LockhartAlzheimer's Disease Research Center Wake Forest School of Medicine Winston‐Salem NC USATimothy M. HughesAlzheimer's Disease Research Center Wake Forest School of Medicine Winston‐Salem NC USAChristopher ChenDepartment of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Memory Aging and Cognition Centre National University Health System SingaporePerminder S. SachdevCentre for Healthy Brain Ageing School of Psychiatry University of New South Wales Australia Sydney AustraliaJohn T. O’BrienDepartment of Psychiatry University of Cambridge School of Clinical Medicine Cambridge UKIngmar SkoogDepartment of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Mölndal SwedenLeonardo Pantoni“L. Sacco” Department of Biomedical and Clinical Sciences University of Milan Milan ItalyDeborah GustafsonDepartment of Neurology State University of New York‐Downstate Medical Center Brooklyn NY USAGeert Jan BiesselsDepartment of Neurology Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The NetherlandsAnders WallinInstitute of Neuroscience and Physiology University of Gothenburg Gothenberg SwedenEric E. SmithHotchkiss Brain Institute University of Calgary Alberta CanadaVincent MokDepartment of Medicine and Therapeutics Therese Pei Fong Chow Research Centre for Prevention of Dementia The Chinese University of Hong Kong Hong Kong SAR ChinaAdrian WongDepartment of Medicine and Therapeutics Therese Pei Fong Chow Research Centre for Prevention of Dementia The Chinese University of Hong Kong Hong Kong SAR ChinaPeter PassmoreSchool of Medicine Dentistry and Biomedical Sciences Queen's University Belfast Belfast UKFrederick BarkofDepartment of Radiology and Nuclear Medicine Amsterdam Neuroscience VU University Medical Center Amsterdam The NetherlandsMajon MullerSection of Geriatrics Department of Internal Medicine VU University Medical Center Amsterdam The NetherlandsMonique M.B. BretelerDepartment of Population Health Sciences German Center for Neurodegenerative Diseases (DZNE) Bonn GermanyGustavo C. RománDepartment of Neurology Methodist Neurological Institute Houston TX USAÉdith HamelLaboratory of Cerebrovascular Research Montreal Neurological Institute McGill University Montréal QC CanadaSudha SeshadriDepartment of Neurology Boston University School of Medicine Boston MA USARebecca F. GottesmanDepartments of Neurology and Epidemiology Johns Hopkins University Baltimore MD USAMark A. van BuchemDepartment of Radiology Leiden University Medical Center Leiden The NetherlandsZoe ArvanitakisDepartment of Neurological Sciences Rush University Medical Center Chicago IL USAJulie A. SchneiderDepartment of Neurological Sciences Rush University Medical Center Chicago IL USALester R. DrewesLaboratory of Cerebral Vascular Biology Department of Biomedical Sciences University of Minnesota Medical School Duluth Duluth MN USAVladimir HachinskiDivision of Neurology Department of Clinical Neurological Sciences Western University London Ontario CanadaCaleb E. FinchLeonard Davis School of Gerontology Dornsife College University of Southern California Los Angeles CA USAArthur W. TogaAlzheimer's Disease Research Center Keck School of Medicine at the University of Southern California Los Angeles CA USAJoanna M. WardlawNeuroimaging Sciences and Brain Research Imaging Center Division of Neuroimaging Sciences Center for Clinical Brain Sciences UK Dementia Research Institute at the University of Edinburgh UKBerislav V. ZlokovićAlzheimer's Disease Research Center Keck School of Medicine at the University of Southern California Los Angeles CA USA
2019en
ABI
Аннотация
Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous disease with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging-Alzheimer's Association describes a biomarker-based pathologic definition of AD focused on amyloid, tau, and neuronal injury. In response to this article, here we first discussed evidence that vascular dysfunction is an important early event in AD pathophysiology. Next, we examined various imaging sequences that could be easily implemented to evaluate different types of vascular dysfunction associated with, and/or contributing to, AD pathophysiology, including changes in blood-brain barrier integrity and cerebral blood flow. Vascular imaging biomarkers of small vessel disease of the brain, which is responsible for >50% of dementia worldwide, including AD, are already established, well characterized, and easy to recognize. We suggest that these vascular biomarkers should be incorporated into the AD Research Framework to gain a better understanding of AD pathophysiology and aid in treatment efforts.
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