Статья

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

Betsy BarnesCenter for Autoimmune, Musculoskeletal and Hematopoietic Diseases, The Feinstein Institutes for Medical Research & Departments of Molecular Medicine and Pediatrics, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 1José M. AdroverCold Spring Harbor Laboratory, Cold Spring Harbor, NY 2Amelia Baxter-StoltzfusDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 3Alain BorczukDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 3Jonathan Cools‐LartigueJames M. CrawfordDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, NY 5Juliane Daßler‐PlenkerCold Spring Harbor Laboratory, Cold Spring Harbor, NY 2Philippe GuerciCentre Hospitalier Universitaire de Nancy, Nancy, France 6Caroline HuynhDivision of Thoracic and Upper GI Surgery, Department of Surgery, Montreal, Canada 4Jason S. KnightDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 8Massimo LodaDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 3Mark R. LooneyDepartment of Medicine, University of California, San Francisco, San Francisco, CA 9Florencia McAllisterDepartment of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, TX 10Roni RayesDivision of Thoracic and Upper GI Surgery, Department of Surgery, Montreal, Canada 4Stéphane RenaudCentre Hospitalier Universitaire de Nancy, Nancy, France 6Simon RousseauDepartment of Medicine, McGill University & The Research Institute of the McGill University Health Centre, Montreal, Canada 11Steven SalvatoreDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 3Robert E. SchwartzDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY 12Jonathan SpicerDivision of Thoracic and Upper GI Surgery, Department of Surgery, Montreal, Canada 4Christian C. YostDepartment of Pediatrics, Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT 13Andrew WeberDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Northwell Health, Manhasset, NY 14Yu ZuoDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 8Mikala EgebladCold Spring Harbor Laboratory, Cold Spring Harbor, NY 2

2020en

ABI

Аннотация

Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10-15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils-the ability to form neutrophil extracellular traps (NETs)-may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19.

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Идентификаторы

DOI: 10.1084/jem.20200652

Цитирования и источники

Цитирований: 2Использованных источников: 0

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