Обзорная статья

Biological interactions of carbon-based nanomaterials: From coronation to degradation

Kunal BhattacharyaDivision of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenSourav P. MukherjeeDivision of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenAudrey GalludDivision of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenSeth C. BurkertDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, USASilvia BistarelliNational Institute of Nuclear Physics-INFN, Frascati, Province of Rome, ItalyStefano BellucciNational Institute of Nuclear Physics-INFN, Frascati, Province of Rome, ItalyMassimo BottiniDepartment of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome, Italy; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United StatesAlexander StarDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, USABengt FadeelDivision of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: [email protected]

2015en

ABI

Аннотация

Carbon-based nanomaterials including carbon nanotubes, graphene oxide, fullerenes and nanodiamonds are potential candidates for various applications in medicine such as drug delivery and imaging. However, the successful translation of nanomaterials for biomedical applications is predicated on a detailed understanding of the biological interactions of these materials. Indeed, the potential impact of the so-called bio-corona of proteins, lipids, and other biomolecules on the fate of nanomaterials in the body should not be ignored. Enzymatic degradation of carbon-based nanomaterials by immune-competent cells serves as a special case of bio-corona interactions with important implications for the medical use of such nanomaterials. In the present review, we highlight emerging biomedical applications of carbon-based nanomaterials. We also discuss recent studies on nanomaterial 'coronation' and how this impacts on biodistribution and targeting along with studies on the enzymatic degradation of carbon-based nanomaterials, and the role of surface modification of nanomaterials for these biological interactions. FROM THE CLINICAL EDITOR: Advances in technology have produced many carbon-based nanomaterials. These are increasingly being investigated for the use in diagnostics and therapeutics. Nonetheless, there remains a knowledge gap in terms of the understanding of the biological interactions of these materials. In this paper, the authors provided a comprehensive review on the recent biomedical applications and the interactions of various carbon-based nanomaterials.

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Идентификаторы

DOI: 10.1016/j.nano.2015.11.011

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Цитирований: 2Использованных источников: 0

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