Статья

A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat

Ahyeon KohDepartment of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USADaeshik KangDepartment of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USAYeguang XueDepartments of Civil and Environmental Engineering, Mechanical Engineering, and Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USASeungmin LeeDepartment of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USARafal M. PielakL’Oréal Technology Incubator, San Francisco, CA 94107, USAJeonghyun KimDepartment of Energy Engineering, Hanyang University, Seoul 133-791, KoreaTaehwan HwangDepartment of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USASeunghwan MinDepartment of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USAAnthony BanksDepartment of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USAPhilippe BastienL’Oréal Research and Innovation, Aulnay-sous-Bois, FranceMegan MancoL’Oréal Early Clinical, Clark, NJ 07066, USALiang WangDepartment of Chemical and Biological Engineering, Institute of Chemical Machinery and Process Equipment, Zhejiang University, Hangzhou 310027, People’s Republic of ChinaKaitlyn R. AmmannDepartment of Medicine and Biomedical Engineering, Sarver Heart Center, University of Arizona, Tucson, AZ 85724, USAKyung‐In JangDepartment of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USAPhillip WonDepartment of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USASeungyong HanDepartment of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USARoozbeh GhaffariMC10 Inc., Cambridge, MA 02140, USAUngyu PaikDepartment of Energy Engineering, Hanyang University, Seoul 133-791, KoreaMarvin J. SlepianDepartment of Medicine and Biomedical Engineering, Sarver Heart Center, University of Arizona, Tucson, AZ 85724, USAGuive BaloochL’Oréal Technology Incubator, San Francisco, CA 94107, USAYonggang HuangDepartments of Civil and Environmental Engineering, Mechanical Engineering, and Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USAJohn A. RogersDepartment of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

2016en

ABI

Аннотация

Capabilities in health monitoring enabled by capture and quantitative chemical analysis of sweat could complement, or potentially obviate the need for, approaches based on sporadic assessment of blood samples. Established sweat monitoring technologies use simple fabric swatches and are limited to basic analysis in controlled laboratory or hospital settings. We present a collection of materials and device designs for soft, flexible, and stretchable microfluidic systems, including embodiments that integrate wireless communication electronics, which can intimately and robustly bond to the surface of the skin without chemical and mechanical irritation. This integration defines access points for a small set of sweat glands such that perspiration spontaneously initiates routing of sweat through a microfluidic network and set of reservoirs. Embedded chemical analyses respond in colorimetric fashion to markers such as chloride and hydronium ions, glucose, and lactate. Wireless interfaces to digital image capture hardware serve as a means for quantitation. Human studies demonstrated the functionality of this microfluidic device during fitness cycling in a controlled environment and during long-distance bicycle racing in arid, outdoor conditions. The results include quantitative values for sweat rate, total sweat loss, pH, and concentration of chloride and lactate.

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Идентификаторы

DOI: 10.1126/scitranslmed.aaf2593

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar