Identification of a Unique Azaphilone Produced by <i>Chaetomium globosum</i> Isolated from <i>Polygonatum sibiricum</i>
Chenggang SongCollege of Plant Science Jilin University Changchun 130062 P. R. ChinaGang DingKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193 P. R. ChinaGang WuCollege of Plant Science Jilin University Changchun 130062 P. R. ChinaJian YangState Key Laboratory of Dao-di Herbs Breeding Base National Resources Center for Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 P. R. ChinaMingzhe ZhangCollege of Plant Science Jilin University Changchun 130062 P. R. ChinaHaoyu WangCollege of Plant Science Jilin University Changchun 130062 P. R. ChinaDongsheng WeiInstitute of Wood Science Department of Biology University of Hamburg Leuschnerstrasse 91 21031 Hamburg GermanyJianchun QinCollege of Plant Science Jilin University Changchun 130062 P. R. ChinaLanping GuoState Key Laboratory of Dao-di Herbs Breeding Base National Resources Center for Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 P. R. China
2020en
ABI
Аннотация
A new azaphilone, chaephilone E, eight azaphilone derivatives, and three chaetoglobosins were isolated from endophytic fungi Chaetomium globosum. The structures of the compounds were elucidated by 1D and 2D NMR as well as HR-ESI-MS data, and the absolute configuration of chaephilone E was established on the basis of electronic circular dichroism and NOESY spectrum. The activity of chaephilone E was evaluated via the cytotoxic assay (human hepatoma cell lines HepG-2) and brine shrimp (Artemia salina) bioassay.
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