Combined Analytical Approaches to Standardize and Characterize Biomaterials Formulations: Application to Chitosan-Gelatin Cross-Linked Hydrogels
Sofia MagliBioNanoMedicine Center, University of Milano-Bicocca, 20126 Milan, ItalyLorenzo RossiBioNanoMedicine Center, University of Milano-Bicocca, 20126 Milan, ItalyCesare ConsentinoG. Ronzoni Institute for Chemical and Biochemical Research, 20126 Milan, ItalySabrina BertiniG. Ronzoni Institute for Chemical and Biochemical Research, 20126 Milan, ItalyFrancesco NicotraBioNanoMedicine Center, University of Milano-Bicocca, 20126 Milan, ItalyLaura RussoBioNanoMedicine Center, University of Milano-Bicocca, 20126 Milan, Italy
2021en
ABI
Аннотация
A protocol based on the combination of different analytical methodologies is proposed to standardize the experimental conditions for reproducible formulations of hybrid hydrogels. The final hybrid material, based on the combination of gelatin and chitosan functionalized with methylfuran and cross-linked with 4-arm-PEG-maleimide, is able to mimic role, dynamism, and structural complexity of the extracellular matrix. Physical-chemical properties of starting polymers and finals constructs were characterized exploiting the combination of HP-SEC-TDA, UV, FT-IR, NMR, and TGA.
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