An Antibacterial Zn–MOF with Hydrazinebenzoate Linkers
Jimmy RestrepoInorganic Chemistry Department University of Alcalá 28805 Alcalá de Henares Madrid SpainZakarias SerroukhDepartment of Chemical Engineering University of Alcalá 28805 Alcalá de Henares Madrid SpainJavier Santiago‐MoralesDepartment of Chemical Engineering University of Alcalá 28805 Alcalá de Henares Madrid SpainSónia AguadoDepartment of Chemical Engineering University of Alcalá 28805 Alcalá de Henares Madrid SpainPilar Gómez‐SalInorganic Chemistry Department University of Alcalá 28805 Alcalá de Henares Madrid SpainMarta E. G. MosqueraInorganic Chemistry Department University of Alcalá 28805 Alcalá de Henares Madrid SpainRoberto RosalDepartment of Chemical Engineering University of Alcalá 28805 Alcalá de Henares Madrid Spain
2016en
ABI
Аннотация
A Zn‐based metal–organic framework (MOF) with hydrazinebenzoate linkers was evaluated as antimicrobial material against the Gram‐positive bacterium Staphylococcus aureus . The material inhibits bacterial growth and metabolic activity, with a half maximal effective concentration of about 20 mg L –1 material dispersed in the culture medium. The antimicrobial effect can be attributed to the release of the 4‐hydrazinebenzoate linker, with a negligible contribution from the free metal. The material exhibits remarkable durability, and it enables the sustained release of the ligand over a period of several days.
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