Practical uses for ecdysteroids in mammals including humans: and update
René LafontUniversité Pierre et Marie Curie, Institut de Biologie Intégrative, Laboratoire d'Endocrinologie Moléculaire et Évolution, 7 Quai Saint Bernard, Case Courrier N° 29, 75252 Paris Cedex 05, FranceLaurence DinanUniversity of Exeter, Department of Biological Sciences, Hatherly Laboratories, Prince of Wales Road, Exeter, Devon, EX4 4PS, U.K
2003en
ABI
Аннотация
Ecdysteroids are widely used as inducers for gene-switch systems based on insect ecdysteroid receptors and genes of interest placed under the control of ecdysteroid-response elements. We review here these systems, which are currently mainly used in vitro with cultured cells in order to analyse the role of a wide array of genes, but which are expected to represent the basis for future gene therapy strategies. Such developments raise several questions, which are addressed in detail.
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