Статья

Enhanced Oral Bioavailability, Anti-Tumor Activity and Hepatoprotective Effect of 6-Shogaol Loaded in a Type of Novel Micelles of Polyethylene Glycol and Linoleic Acid Conjugate

Huiyun ZhangCenter for Nano Drug/Gene Delivery and Tissue Engineering, Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaQilong WangCenter for Nano Drug/Gene Delivery and Tissue Engineering, Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaCongyong SunCenter for Nano Drug/Gene Delivery and Tissue Engineering, Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaYuan ZhuCenter for Nano Drug/Gene Delivery and Tissue Engineering, Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaQiuxuan YangCenter for Nano Drug/Gene Delivery and Tissue Engineering, Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaQiuyu WeiCenter for Nano Drug/Gene Delivery and Tissue Engineering, Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaJiaxin ChenCenter for Nano Drug/Gene Delivery and Tissue Engineering, Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaWenwen DengCenter for Nano Drug/Gene Delivery and Tissue Engineering, Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaMichael Adu‐FrimpongCenter for Nano Drug/Gene Delivery and Tissue Engineering, Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaJiangnan YuCenter for Nano Drug/Gene Delivery and Tissue Engineering, Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaXiming XuCenter for Nano Drug/Gene Delivery and Tissue Engineering, Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, China

2019en

ABI

Аннотация

6-shogaol is a promising anti-cancer and anti-inflammatory agent. However, the treatment effectiveness of 6-shogaol is limited by poor water solubility, poor oral absorption and rapid metabolism. Herein, 6-shogaol loaded in micelles (SMs) were designed to improve 6-shogaol’s solubility and bioavailability. The micelles of a PEG derivative of linoleic acid (mPEG2k-LA) were prepared by the nanoprecipitation method with a particle size of 76.8 nm, and entrapment of 81.6 %. Intriguingly, SMs showed a slower release in phosphate buffer saline (PBS) (pH = 7.4) compared to free 6-shogaol while its oral bioavailability increased by 3.2–fold in vivo. More importantly, the in vitro cytotoxic effect in HepG2 cells of SMs was significantly higher than free 6-shogaol. Furthermore, SMs could significantly improve the tissue distribution of 6-shogaol, especially liver and brain. Finally, SMs showed a better hepatoprotective effect against carbon tetrachloride (CCl4)-induced hepatic injury in vivo than free 6-shogaol. These results suggest that the novel micelles could potentiate the activities of 6-shogaol in cancer treatment and hepatoprotection.

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Идентификаторы

DOI: 10.3390/pharmaceutics11030107

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar