On Volterra and orthogonality preserving quadratic stochastic operators

Introduction: The study on trabeculectomy success rate in Malaysian population
\nwas relatively scarce. Information on trabeculectomy success rate and prognostic
\nfactors for trabeculectomy outcome is needed to help ophthalmologist to
\ndetermine the prognosis and search for better way to increase success rate of
\ntrabeculectomy.
\nObjectives: To detennine the five year trabeculectomy success rate and to
\nidentify the prognostic factors that may influence the trabeculectomy outcome
\namong glaucoma patients treated at HUSM.
\nMethodology: A retrospective record review study was conducted involving 96
\nglaucoma patients (96 eyes) who undetwent trabeculectomy from 1·S I January
\n1990 to 31st July 2006. Additional follow-up of one year after the recruitment of
\nthe study subjects was done from 151 August 2006to31 si July 2007. All patients
\nwho fulfilled the selection criteria were included in the study. The medical
\nrecords were reviewed by a single researcher with the help of senior consultant of
\nophthalmology and important information on the variables of interest and
\ntrabeculectomy outcome status were collected and recorded into a clinical form .
\nThe Kaplan Meier and Cox Proportional Hazards regression analysis was used in
\nstatistical analysis.
\nResults: The median trabeculectomy success time was 18.8 months and the
\noverall trabeculectomy success rate was 36. l % (95% CI: 25.6, 46.8) at five year.
\nBased on the Cox's regression analysis after adjusting other va1iables, the
\nsignificant prognostic factors that may influence trabeculectomy outcome was
\nhistory of previous ocular surgery (HR=2.31, 95% Cl: 1.21, 4.41; p=0.019).
\nConclusion: Trabeculectomy success rate for glaucoma patients at HUSM was
\nacceptably low. The history of previous ocular surgery was identified as the only
\nsignificant prognostic factor for trabeculectomy failure.
\nBetter post trabeculectomy management for glaucoma patient that had undergone
\nprevious ocular surgery is recommended to obtain higher trabeculectomy success
\nrate in those patient.

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