Статья

The Clinical Characteristics and Outcomes of Patients with Moderate-to-Severe Coronavirus Disease 2019 Infection and Diabetes in Daegu, South Korea

Mi Kyung KimDepartment of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, KoreaJae‐Han JeonDepartment of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, KoreaSung-Woo KimDepartment of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, KoreaJun Sung MoonDepartment of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, KoreaNan Hee ChoDepartment of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, KoreaEugene HanDepartment of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, KoreaJi Hong YouDepartment of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, KoreaJi Yeon LeeDepartment of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, KoreaMiri HyunDepartment of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, KoreaJae Seok ParkDepartment of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, KoreaYong Shik KwonDepartment of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, KoreaYeon‐Kyung ChoiDepartment of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, KoreaKi Tae KwonDepartment of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, KoreaShin Yup LeeDepartment of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, KoreaEon Ju JeonDepartment of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, KoreaJin‐Woo KimDepartment of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, KoreaHyo‐Lim HongDepartment of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, KoreaHyun Hee KwonDepartment of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, KoreaChi Young JungDepartment of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, KoreaYin Young LeeDepartment of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, KoreaEunyeoung HaDepartment of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, KoreaSeung Min ChungDepartment of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, KoreaJian HurDepartment of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, KoreaJune Hong AhnDepartment of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, KoreaNayoung KimDepartment of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, KoreaShin‐Woo KimDepartment of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, KoreaHyun‐Ha ChangDepartment of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, KoreaYong Hoon LeeDepartment of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, KoreaJaehee LeeDepartment of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, KoreaKeun‐Gyu ParkDepartment of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, KoreaHyun Ah KimDepartment of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, KoreaJi Hyun LeeDepartment of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, Korea

2020en

ABI

Аннотация

BACKGROUND: Coronavirus disease 2019 (COVID-19) is a global pandemic that had affected more than eight million people worldwide by June 2020. Given the importance of the presence of diabetes mellitus (DM) for host immunity, we retrospectively evaluated the clinical characteristics and outcomes of moderate-to-severe COVID-19 in patients with diabetes. METHODS: We conducted a multi-center observational study of 1,082 adult inpatients (aged ≥18 years) who were admitted to one of five university hospitals in Daegu because of the severity of their COVID-19-related disease. The demographic, laboratory, and radiologic findings, and the mortality, prevalence of severe disease, and duration of quarantine were compared between patients with and without DM. In addition, 1:1 propensity score (PS)-matching was conducted with the DM group. RESULTS: =235) were older, exhibited higher mortality, and required more intensive care. Even after PS-matching, patients with DM exhibited more severe disease, and DM remained a prognostic factor for higher mortality (hazard ratio, 2.40; 95% confidence interval, 1.38 to 4.15). Subgroup analysis revealed that the presence of DM was associated with higher mortality, especially in older people (≥70 years old). Prior use of a dipeptidyl peptidase-4 inhibitor or a renin-angiotensin system inhibitor did not affect mortality or the clinical severity of the disease. CONCLUSION: DM is a significant risk factor for COVID-19 severity and mortality. Our findings imply that COVID-19 patients with DM, especially if elderly, require special attention and prompt intensive care.

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Идентификаторы

DOI: 10.4093/dmj.2020.0146

Цитирования и источники

Цитирований: 2Использованных источников: 0

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