Forty-Year Journey of Angiogenesis Translational Research
Yihai CaoDepartment of Medicine and Health Sciences, Linköping University, 581 83 Linköping, SwedenJack L. ArbiserDepartment of Dermatology, Atlanta Veterans Administration Health Center, Emory University School of Medicine, Atlanta, GA 30322, USARobert J. D’AmatoDepartment of Surgery, Children’s Hospital, Boston, MA 02115, USAPatrìcia A. D'AmoreDepartment of Ophthalmology, Schepens Eye Research Institute/Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USADonald E. IngberVascular Biology Program, Children’s Hospital, Boston, MA 02115, USARobert S. KerbelDivision of Molecular and Cellular Biology Research, Sunnybrook Health Sciences Centre, S-217 Research Building, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, CanadaMichael KlagsbrunDepartment of Surgery, Children’s Hospital, Boston, MA 02115, USASharon LimDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, SwedenMarsha A. MosesDepartment of Surgery, Children’s Hospital, Boston, MA 02115, USABruce R. ZetterDepartment of Surgery, Children’s Hospital, Boston, MA 02115, USAHarold F. DvorakCenter for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USARóbert LangerDepartment of Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
2011en
ABI
Аннотация
Forty years ago, Judah Folkman predicted that tumor growth is dependent on angiogenesis and that inhibiting this process might be a new strategy for cancer therapy. This hypothesis formed the foundation of a new field of research that represents an excellent example of how a groundbreaking scientific discovery can be translated to yield benefits for patients. Today, antiangiogenic drugs are used to treat human cancers and retinal vascular diseases. Here, we guide readers through 40 years of angiogenesis research and discuss challenges of antiangiogenic therapy.
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