Обзорная статья

miRNA-based biomarkers, therapies, and resistance in Cancer

Boxue HeDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaZhenyu ZhaoDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaQidong CaiDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaYuqian ZhangDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaPengfei ZhangDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaShuai ShiDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaHui XieDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaXiong PengDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaWei YinDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaYongguang TaoDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaXiang WangDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China

2020en

ABI

Аннотация

MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in size, play important roles in gene regulation, and their dysregulation is implicated in human diseases including cancer. A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor immune, and function with miRNA sponges. During the last two decades, the connection between miRNAs and various cancers has been widely researched. Based on evidence about miRNA, numerous potential cancer biomarkers for the diagnosis and prognosis have been put forward, providing a new perspective on cancer screening. Besides, there are several miRNA-based therapies among different cancers being conducted, advanced treatments such as the combination of synergistic strategies and the use of complementary miRNAs provide significant clinical benefits to cancer patients potentially. Furthermore, it is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis. With the belief that studies about miRNAs in human cancer would have great clinical implications, we attempt to summarize the current situation and potential development prospects in this review.

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Идентификаторы

DOI: 10.7150/ijbs.47203

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar