Обзорная статья

Angiogenesis-related non-coding RNAs and gastrointestinal cancer

Zahra RazaviSchool of Medicine, Kashan University of Medical Sciences, Kashan, IranKasra AsgarpourDepartment of Medicine, University of Western Ontario, London, ON, CanadaMaryam Mahjoubin‐TehranDepartment of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranSusan RasouliSchool of Medicine, Kashan University of Medical Sciences, Kashan, IranHaroon KhanDepartment of Pharmacy, Abdul Wali Khan University Mardan, Mardan, PakistanMohammad Karim ShahrzadDepartment of Internal Medicine and Endocrinology, Shohadae Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranMichael R. HamblinLaser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South AfricaHamed MirzaeiResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

2021en

ABI

Аннотация

Gastrointestinal (GI) cancers are among the main reasons for cancer death globally. The deadliest types of GI cancer include colon, stomach, and liver cancers. Multiple lines of evidence have shown that angiogenesis has a key role in the growth and metastasis of all GI tumors. Abnormal angiogenesis also has a critical role in many non-malignant diseases. Therefore, angiogenesis is considered to be an important target for improved cancer treatment. Despite much research, the mechanisms governing angiogenesis are not completely understood. Recently, it has been shown that angiogenesis-related non-coding RNAs (ncRNAs) could affect the development of angiogenesis in cancer cells and tumors. The broad family of ncRNAs, which include long non-coding RNAs, microRNAs, and circular RNAs, are related to the development, promotion, and metastasis of GI cancers, especially in angiogenesis. This review discusses the role of ncRNAs in mediating angiogenesis in various types of GI cancers and looks forward to the introduction of mimetics and antagonists as possible therapeutic agents.

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Идентификаторы

DOI: 10.1016/j.omto.2021.04.002

Цитирования и источники

Цитирований: 6Использованных источников: 0

Показатели — AkademScholar