Обзорная статья

MicroRNA: Relevance to stroke diagnosis, prognosis, and therapy

Hamed MirzaeiDepartment of Immunology School of Medicine Tehran University of Medical Sciences Tehran IranFatemeh MomeniSchool of Medicine Isfahan University of Medical Sciences Isfahan IranLeila SaadatpourDepartment of Neurology University of Florida College of Medicine Gainesville FloridaAmirhossein SahebkarBiotechnology Research Center Mashhad University of Medical Sciences Mashhad IranMohammad GoodarziFaculty of Bioscience Engineering Department of Biosystems Katholieke Universiteit Leuve—KULeuven Heverlee BelgiumAria MasoudifarDepartment of Molecular Biotechnology Cell Science Research Center Royan Institute for Biotechnology, ACECR Isfahan IranShirin KouhpayehDepartment of Immunology, School of Medicine Isfahan University of Medical Sciences Isfahan IranHossein SalehiDepartment of Anatomical Sciences School of Medicine Isfahan University of Medical Sciences Isfahan IranHamid Reza MirzaeiDepartment of Immunology School of Medicine Tehran University of Medical Sciences Tehran IranMahmoud Reza JaafariNanotechnology Research Center Mashhad University of Medical Sciences Mashhad Iran

2017en

ABI

Аннотация

Stroke is a life-threatening disease that accounts for a considerable burden of mortality in both developing and developed world. Identification of specific biomarkers for stroke and its outcomes can greatly contribute to improved care of patients. MicroRNAs (miRNAs) are known as novel biomarkers that could be used as diagnostic, prognostic, and therapeutic biomarkers. Various studies have shown that miRNAs have key roles in the pathogenesis of stroke, and its complications and outcomes. In addition, there is evidence showing that mesenchaymal stromal cell-derived exosomes containing miRNAs can be used for monitoring and treatment of various diseases such as stroke. Here, we summarized various aspects of miRNA applications in different stages of stroke.

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Идентификаторы

DOI: 10.1002/jcp.25787

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Цитирований: 2Использованных источников: 0

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