Circular Rnas: New Genetic Tools in Melanoma
Jamal HallajzadehDepartment of Biochemistry & Nutrition, Research Center for Evidence-Based Health Management, Maragheh University of Medical Sciences, Maragheh, IranElaheh AmiraniResearch Center for Biochemistry & Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IranHamed MirzaeiResearch Center for Biochemistry & Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IranRana ShafabakhshResearch Center for Biochemistry & Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IranSeyyed Mehdi MirhashemiMetabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, IranMehran SharifiDepartment of Hematology & Oncology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBahman YousefiStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, IranMohammad Alì MansourniaDepartment of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IranZatollah AsemiResearch Center for Biochemistry & Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
2020en
ABI
Аннотация
Melanoma is the most lethal form of skin cancer. New technologies have resulted in major advances in the diagnosis and treatment of melanoma and other cancer types. Recently, some studies have investigated the role of circular RNAs (circRNAs) in different cancers. CircRNAs are a member of long noncoding RNA family mainly formed through back-splicing and have a closed-loop structure. These molecules affect several biological and oncogenic cascades in diverse ways via acting as microRNA sponge, interacting with RNA-binding proteins and acting as a transcription regulator. In this review, we made an insight into the impact of circRNA dysregulation in the melanoma tumorigenesis based on the presented evidences.
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