Обзорная статья

Circular RNAs: New Epigenetic Signatures in Viral Infections

Javid Sadri NahandDepartment of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, IranSogol JamshidiDepartment of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, IranMichael R. HamblinDepartment of Dermatology, Harvard Medical School, Boston, MA, United StatesMaryam Mahjoubin‐TehranDepartment of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranMassoud VosoughDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, IranMarzieh JamaliDepartment of Gynecology and Obstetrics, Mahdieh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranAlireza KhatamiDepartment of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, IranMohsen MoghoofeiDepartment of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, IranHossein Bannazadeh BaghiImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranHamed MirzaeiResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

2020en

ABI

Аннотация

Covalent closed circular RNAs (circRNAs) can act as a bridge between non-coding RNAs and coding messenger RNAs. CircRNAs are generated by a back-splicing mechanism during post-transcriptional processing and are abundantly expressed in eukaryotic cells. CircRNAs can act via the modulation of RNA transcription and protein production, and by the sponging of microRNAs (miRNAs). CircRNAs are now thought to be involved in many different biological and pathological processes. Some studies have suggested that the expression of host circRNAs is dysregulated in several types of virus-infected cells, compared to control cells. It is highly likely that viruses can use these molecules for their own purposes. In addition, some viral genes are able to produce viral circRNAs (VcircRNA) by a back-splicing mechanism. However, the viral genes that encode VcircRNAs, and their functions, are poorly studied. In this review, we highlight some new findings about the interaction of host circRNAs and viral infection. Moreover, the potential of VcircRNAs derived from the virus itself, to act as biomarkers and therapeutic targets is summarized.

Перевод пока недоступен

Идентификаторы

DOI: 10.3389/fmicb.2020.01853

Цитирования и источники

Цитирований: 9Использованных источников: 0

Показатели — AkademScholar