Обзорная статья

Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages

Kasra AsgarpourDepartment of Medicine, University of Western Ontario, London, Ontario, CanadaZahra ShojaeiSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranFatemeh AmiriSchool of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, IranJafar AiDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine (SATM), Tehran University of Medical Sciences (TUMS), Tehran, IranMaryam Mahjoubin‐TehranDepartment of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranFaezeh GhasemiBlood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, IranReza ArefnezhadDepartment of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranMichael R. HamblinWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 40 Blossom Street, Boston, MA, 02114, USA. [email protected]Hamed MirzaeiResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, IR, Iran. [email protected]

2020en

ABI

Аннотация

Exosomes are extracellular vesicles characterized by their size, source, release mechanism and contents. MicroRNAs (miRNAs) are single stranded non-coding RNAs transcribed from DNA. Exosomes and miRNAs are widespread in eukaryotic cells, especially in mesenchymal stem cells (MSCs). MSCs are used for tissue regeneration, and also exert paracrine, anti-inflammatory and immunomodulatory effects. However, the use of MSCs is controversial, especially in the presence or after the remission of a tumor, due to their secretion of growth factors and their migration ability. Instead of intact MSCs, MSC-derived compartments or substances could be used as practical tools for diagnosis, follow up, management and monitoring of diseases. Herein, we discuss some aspects of exosomal miRNAs derived from MSCs in the progression, diagnosis and treatment of various diseases. Video Abstract.

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Идентификаторы

DOI: 10.1186/s12964-020-00650-6

Цитирования и источники

Цитирований: 4Использованных источников: 0

Показатели — AkademScholar