New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs
Maryam Mahjoubin‐TehranStudent Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranSamaneh RezaeiStudent Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranAmin JesmaniDepartment of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranNafise BirangDepartment of Physical Medicine and Rehabilitation, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranKorosh MorshediSchool of Medicine, Kashan University of Medical Sciences, Kashan, IranHashem KhanbabaeiMedical Physics Department, School of Medicine, Kerman University of Medical Sciences, Kerman, IranHaroon KhanDepartment of Pharmacy, Abdul Wali Khan University, Mardan 23200, PakistanAshkan PiranvisehBrain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected]Majid NejatiAnatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: [email protected]Michael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10463, USAHamed MirzaeiResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: [email protected]
2021en
ABI
Аннотация
Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke.
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