MiRNA-148b and Its Role in Various Cancers
Najmeh DorrakiDepartment of Medical Genetics, Faculty of Medicine, Mashhad University of Medical SciencesZari Naderi Ghale-NoieDepartment of Medical Genetics, Faculty of Medicine, Mashhad University of Medical SciencesNooshin Sadegh AhmadiDepartment of Genetics, Faculty of Medicine, Tehran Medical Sciences Islamic Azad UniversityVahideh KeyvaniDepartment of Biology, Faculty of Science, Shahid Chamran University of AhvazRosita Azar BahadoriDepartment of Biology, Parand Branch, Islamic Azad UniversityArash Salmani NejadDepartment of Medical Genetics, Faculty of Medicine, Mashhad University of Medical SciencesMichael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of MedicineHossein PourghadamyariDepartment of Clinical Biochemistry, Afzalipour School of Medicine, Kerman University of Medical SciencesSamaneh MollazadehNatural Products & Medicinal Plants Research Center, North Khorasan University of Medical SciencesHamed MirzaeiResearch Center for Biochemistry & Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences
2021en
ABI
Аннотация
miRNA-148b belongs to the family miR-148/-152, with significant differences in nonseed sequences, which can target diverse mRNA molecules. Reportedly, it may undergo deregulation in lung and ovarian cancers and downregulation in gastric, pancreatic and colon cancers. However, there is a need for further studies to better characterize its mechanism of action and in different types of cancer. In this review, we focus on the aberrant expression of miR-148b in different cancer types and highlight its main target genes and signaling pathways, as well as its pathophysiologic role and relevance to tumorigenesis in several types of cancer.
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