Обзорная статья

Non-Coding RNAs and Brain Tumors: Insights Into Their Roles in Apoptosis

Omid Reza TamtajiStudents' Scientific Research Center, Tehran University of Medical Sciences, Tehran, IranMaryam DerakhshanDepartment of Pathology, Isfahan University of Medical Sciences, Isfahan, IranFatemeh Zahra Rashidi NoshabadStudent Research Committee, Kashan University of Medical Sciences, Kashan, IranJavad RazaviyanStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranRazie HadaviStudents' Scientific Research Center, Tehran University of Medical Sciences, Tehran, IranHamed JafarpourStudent Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, IranAmeneh JafariAdvanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, IranAli RajabiSchool of Medicine, Kashan University of Medical Sciences, Kashan, IranMichael R. HamblinLaser Research Centre, Faculty of Health Science, University of Johannesburg, Johannesburg, South AfricaMahmood Khaksary MahabadyAnatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, IranMohammad TaghizadiehDepartment of Pathology, School of Medicine, Center for Women's Health Research Zahra, Tabriz University of Medical Sciences, Tabriz, IranHamed MirzaeiResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

2022en

ABI

Аннотация

A major terrifying ailment afflicting the humans throughout the world is brain tumor, which causes a lot of mortality among pediatric and adult solid tumors. Several major barriers to the treatment and diagnosis of the brain tumors are the specific micro-environmental and cell-intrinsic features of neural tissues. Absence of the nutrients and hypoxia trigger the cells' mortality in the core of the tumors of humans' brains: however, type of the cells' mortality, including apoptosis or necrosis, has been not found obviously. Current studies have emphasized the non-coding RNAs (ncRNAs) since their crucial impacts on carcinogenesis have been discovered. Several investigations suggest the essential contribution of such molecules in the development of brain tumors and the respective roles in apoptosis. Herein, we summarize the apoptosis-related non-coding RNAs in brain tumors.

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Идентификаторы

DOI: 10.3389/fcell.2021.792185

Цитирования и источники

Цитирований: 5Использованных источников: 0

Показатели — AkademScholar