Effects of Micrornas and Long Non-Coding RNAs on Chemotherapy Response in Glioma
Sara AhmadpourDepartment of Biotechnology, Faculty of Chemistry, University of Kashan, Kashan, IranTarannomsadat TaghaviDepartment of Cell & Moleclar Biology, University of Tehran, Tehran, IranAmirhossein SheidaSchool of Medicine, Kashan University of Medical Sciences, Kashan, IranSeyed Saeed Tamehri ZadehSchool of Medicine, Tehran University of Medical Sciences, Tehran, IranMichael R. HamblinLaser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South AfricaHamed MirzaeiResearch Center for Biochemistry & Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
2022en
ABI
Аннотация
Glioma is the most prevalent invasive primary tumor of the central nervous system. Glioma cells can spread and infiltrate into normal surrounding brain tissues. Despite the standard use of chemotherapy and radiotherapy after surgery in glioma patients, treatment resistance is still a problem, as the underlying mechanisms are still not fully understood. Non-coding RNAs are widely involved in tumor progression and treatment resistance mechanisms. In the present review, we discuss the pathways by which microRNAs and long non-coding RNAs can affect resistance to chemotherapy and radiotherapy, as well as offer potential therapeutic options for future glioma treatment.
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