Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
Xavi Solé‐MartíBarcelona Research Center in Multiscale Science and Engineering, UPC, 08019 Barcelona, SpainTània VilellaBarcelona Research Center in Multiscale Science and Engineering, UPC, 08019 Barcelona, SpainCédric LabayBarcelona Research Center in Multiscale Science and Engineering, UPC, 08019 Barcelona, SpainFrancesco TampieriBarcelona Research Center in Multiscale Science and Engineering, UPC, 08019 Barcelona, SpainMaria‐Pau GinebraBarcelona Research Center in Multiscale Science and Engineering, UPC, 08019 Barcelona, SpainCristina CanalBarcelona Research Center in Multiscale Science and Engineering, UPC, 08019 Barcelona, Spain
2022en
ABI
Аннотация
therapies. In this work, we optimized the composition of a methylcellulose (MC) hydrogel to confer it with the ability to form a gel at physiological temperatures while remaining in the liquid phase at room temperature to allow gas-plasma treatment with suitable formation of plasma-generated RONS. MC hydrogels demonstrated the capacity for generation, prolonged storage and release of RONS. This release induced cytotoxic effects on the osteosarcoma cancer cell line MG-63, reducing its cell viability in a dose-response manner. These promising results postulate plasma-treated thermosensitive hydrogels as good candidates to provide local anticancer therapies.
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