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Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD-based protein subunit vaccine (ZF2001) against COVID-19 in adults: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials

Shilong YangYan LiCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaLianpan DaiCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaJianfeng WangNational Institute for Food and Drug Control, Beijing, ChinaPeng HeNational Institute for Food and Drug Control, Beijing, ChinaChanggui LiNational Institute for Food and Drug Control, Beijing, ChinaXin FangNational Institute for Food and Drug Control, Beijing, ChinaChenfei WangNational Institute for Food and Drug Control, Beijing, ChinaXiang ZhaoNational Institute for Food and Drug Control, Beijing, ChinaEnqi HuangChangwei W. WuZaixin ZhongFengze WangCAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaXiaomin DuanCAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaSiyu TianCAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaLili WuCAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaYan LiuYi LuoZhihai ChenCenter of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaFangjun LiHunan Provincial Center for Disease Control and Prevention, Changsha, ChinaJunhua LiHunan Provincial Center for Disease Control and Prevention, Changsha, ChinaXian YuThe Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaHong RenThe Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaLihong LiuBeijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaShufang MengNational Institute for Food and Drug Control, Beijing, ChinaJinghua YanCAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaZhongyu HuNational Institute for Food and Drug Control, Beijing, ChinaLidong GaoHunan Provincial Center for Disease Control and Prevention, Changsha, China. Electronic address: [email protected]George F. GaoCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. Electronic address: [email protected]
2021en
ABI

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