Обзорная статья

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

Bence GyörgyDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Nagyvárad tér, HungaryTamás SzabóDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Nagyvárad tér 4, Budapest, 1089, HungaryMária PásztóiDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Nagyvárad tér 4, Budapest, 1089, HungaryZsuzsanna PálDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Nagyvárad tér 4, Budapest, 1089, HungaryPetra MisjákDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Nagyvárad tér 4, Budapest, 1089, HungaryBorbála AradiDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Nagyvárad tér 4, Budapest, 1089, HungaryValéria LászlóDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Nagyvárad tér 4, Budapest, 1089, HungaryÉva PállingerDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Nagyvárad tér 4, Budapest, 1089, HungaryErna PapDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Nagyvárad tér 4, Budapest, 1089, HungaryÁgnes KittelInstitute of Experimental Medicine, Hungarian Academy of Sciences, Szigony utca 43, Budapest, HungaryGyörgy NagyDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Nagyvárad tér 4, Budapest, 1089, HungaryAndrás FalusDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Nagyvárad tér 4, Budapest, 1089, HungaryEdit I. BuzásDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Nagyvárad tér 4, Budapest, 1089, Hungary

2011en

ABI

Аннотация

Release of membrane vesicles, a process conserved in both prokaryotes and eukaryotes, represents an evolutionary link, and suggests essential functions of a dynamic extracellular vesicular compartment (including exosomes, microparticles or microvesicles and apoptotic bodies). Compelling evidence supports the significance of this compartment in a broad range of physiological and pathological processes. However, classification of membrane vesicles, protocols of their isolation and detection, molecular details of vesicular release, clearance and biological functions are still under intense investigation. Here, we give a comprehensive overview of extracellular vesicles. After discussing the technical pitfalls and potential artifacts of the rapidly emerging field, we compare results from meta-analyses of published proteomic studies on membrane vesicles. We also summarize clinical implications of membrane vesicles. Lessons from this compartment challenge current paradigms concerning the mechanisms of intercellular communication and immune regulation. Furthermore, its clinical implementation may open new perspectives in translational medicine both in diagnostics and therapy.

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Идентификаторы

DOI: 10.1007/s00018-011-0689-3

Цитирования и источники

Цитирований: 3Использованных источников: 0

Показатели — AkademScholar